If you are looking for a new job in the same line of work, you can deduct the cost of preparing and mailing your resume to prospective employers along with fees paid to placement agencies.

If you travel to look for a new job, you may be able to deduct the cost of your trip.  The IRS has specific guidelines for deducting business travel expenses and they can be read here.

Job search expenses are listed on Schedule A.

Reimbursed expenses cannot be deducted.

Expenses incurred for looking for a first job or a the first job in a long time cannot be deducted.